TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer.

@article{Reig2016TMPRSS2ERGIB,
  title={TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-resistant Prostate Cancer.},
  author={{\`O}scar Reig and Mercedes Mar{\'i}n-Aguilera and Gemma Carrera and N. Jim{\'e}nez and Laia Par{\'e} and Susana Garc{\'i}a-Recio and Lydia Garcia Gaba and Mar{\'i}a Ver{\'o}nica Pereira and Pedro Lu{\'i}s Fern{\'a}ndez and Aleix Prat and Bego{\~n}a Mellado},
  journal={European urology},
  year={2016},
  volume={70 5},
  pages={
          709-713
        }
}
TMPRSS2-ERG rearrangement is a genetic alteration exclusive to prostate cancer, associated with taxane resistance in preclinical models. Its detection in blood samples of metastatic resistant prostate cancer (mCRPC) patients may indicate the presence of circulating tumour cells with this genetic alteration and may predict taxane resistance. To test this hypothesis, we evaluated TMPRSS2-ERG expression using quantitative reverse transcription polymerase chain reaction in peripheral blood… CONTINUE READING

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