TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation

  title={TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation},
  author={Y. Hashimoto and M. Shirane and K. Nakayama},
  journal={Genes to Cells},
  pages={418 - 434}
  • Y. Hashimoto, M. Shirane, K. Nakayama
  • Published 2018
  • Biology, Medicine
  • Genes to Cells
  • Mammalian/mechanistic target of rapamycin complex 1 (mTORC1) responds to growth factors and nutrient availability. Amino acids induce the recruitment of mTORC1 to the lysosomal membrane and its consequent activation, but the molecular mechanism of such activation has remained unclear. We have now examined the role of TMEM55B, a lysosomal protein of unknown molecular function, in this process on the basis of the results of proteomics and immunofluorescence analyses showing that TMEM55B interacts… CONTINUE READING
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