TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.

  title={TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.},
  author={Daniel B Graham and Ariel Lefkovith and Patrick Deelen and Niek de Klein and M. Varma and Angela Boroughs and A. Desch and Aylwin C. Y. Ng and Gaelen Guzman and M. Schenone and Christine P. Petersen and A. Bhan and Manuel A. Rivas and M. Daly and S. Carr and C. Wijmenga and R. Xavier},
  journal={Cell reports},
  volume={17 11},
  • Daniel B Graham, Ariel Lefkovith, +14 authors R. Xavier
  • Published 2016
  • Biology, Chemistry, Medicine
  • Cell reports
  • Significant insights into disease pathogenesis have been gleaned from population-level genetic studies; however, many loci associated with complex genetic disease contain numerous genes, and phenotypic associations cannot be assigned unequivocally. In particular, a gene-dense locus on chromosome 11 (61.5-61.65 Mb) has been associated with inflammatory bowel disease, rheumatoid arthritis, and coronary artery disease. Here, we identify TMEM258 within this locus as a central regulator of… CONTINUE READING
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