TMEM16A confers receptor-activated calcium-dependent chloride conductance

  title={TMEM16A confers receptor-activated calcium-dependent chloride conductance},
  author={Young Duk Yang and Hawon Cho and Jae Yeon Koo and Min Ho Tak and Yeongyo Cho and Won-Sik Shim and Seung Pyo Park and Jesun Lee and Byeongjun Lee and Byung-Moon Kim and Ramin Raouf and Young Ki Shin and Uhtaek Oh},
Calcium (Ca2+)-activated chloride channels are fundamental mediators in numerous physiological processes including transepithelial secretion, cardiac and neuronal excitation, sensory transduction, smooth muscle contraction and fertilization. Despite their physiological importance, their molecular identity has remained largely unknown. Here we show that transmembrane protein 16A (TMEM16A, which we also call anoctamin 1 (ANO1)) is a bona fide Ca2+-activated chloride channel that is activated by… CONTINUE READING
Highly Influential
This paper has highly influenced 65 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 602 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 345 extracted citations

Cellular functions of TMEM16/anoctamin

Pflügers Archiv - European Journal of Physiology • 2016
View 8 Excerpts
Highly Influenced

Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia.

Proceedings of the National Academy of Sciences of the United States of America • 2015
View 9 Excerpts
Highly Influenced

Multiple transcripts of anoctamin genes expressed in the mouse submandibular salivary gland

Journal of periodontal & implant science • 2015
View 4 Excerpts
Highly Influenced

Two Ca2+-Binding Sites Cooperatively Couple Together in TMEM16A Channel

The Journal of Membrane Biology • 2015
View 5 Excerpts
Highly Influenced

603 Citations

Citations per Year
Semantic Scholar estimates that this publication has 603 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 47 references

Calcium-activated chloride channels.

Annual review of physiology • 2005
View 4 Excerpts
Highly Influenced

Attenuation of store - operated Ca 2 1 current impairs salivary gland fluid secretion in TRPC 1 2 / 2 mice

X. Liu
Proc . Natl Acad . Sci . USA • 2007

Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice.

Proceedings of the National Academy of Sciences of the United States of America • 2007

Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display

A Carles
Oncogene 25, • 2006