TMEM16A confers receptor-activated calcium-dependent chloride conductance

@article{Yang2008TMEM16ACR,
  title={TMEM16A confers receptor-activated calcium-dependent chloride conductance},
  author={Youngduk Yang and Hawon Cho and J. Koo and M. Tak and Yeongyo Cho and W. Shim and Seung Pyo Park and Jesun Lee and B. Lee and B. M. Kim and R. Raouf and Young Ki Shin and U. Oh},
  journal={Nature},
  year={2008},
  volume={455},
  pages={1210-1215}
}
Calcium (Ca2+)-activated chloride channels are fundamental mediators in numerous physiological processes including transepithelial secretion, cardiac and neuronal excitation, sensory transduction, smooth muscle contraction and fertilization. Despite their physiological importance, their molecular identity has remained largely unknown. Here we show that transmembrane protein 16A (TMEM16A, which we also call anoctamin 1 (ANO1)) is a bona fide Ca2+-activated chloride channel that is activated by… Expand
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