TMEM16A and TMEM16B channel proteins generate Ca2+-activated Cl− current and regulate melatonin secretion in rat pineal glands

@article{Yamamura2017TMEM16AAT,
  title={TMEM16A and TMEM16B channel proteins generate Ca2+-activated Cl− current and regulate melatonin secretion in rat pineal glands},
  author={H. Yamamura and K. Nishimura and Y. Hagihara and Y. Suzuki and Y. Imaizumi},
  journal={The Journal of Biological Chemistry},
  year={2017},
  volume={293},
  pages={1006 - 995}
}
Pinealocytes regulate circadian rhythm by synthesizing and secreting melatonin. These cells generate action potentials; however, the contribution of specific ion channels to melatonin secretion from pinealocytes remains unclear. In this study, the involvement and molecular identity of Ca2+-activated Cl− (ClCa) channels in the regulation of melatonin secretion were examined in rat pineal glands. Treatment with the ClCa channel blockers, niflumic acid or T16Ainh-A01, significantly reduced… Expand
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References

SHOWING 1-10 OF 51 REFERENCES
TMEM16B induces chloride currents activated by calcium in mammalian cells
  • 183
TMEM16A confers receptor-activated calcium-dependent chloride conductance
  • 1,029
Spontaneous and nicotine-induced Ca2+ oscillations mediated by Ca2+ influx in rat pinealocytes.
  • 9
  • PDF
TMEM16B, A Novel Protein with Calcium-Dependent Chloride Channel Activity, Associates with a Presynaptic Protein Complex in Photoreceptor Terminals
  • 183
  • PDF
Neurotransmitter-induced novel modulation of a nonselective cation channel by a cAMP-dependent mechanism in rat pineal cells.
  • 26
  • PDF
Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing*
  • 179
  • PDF
Norepinephrine activates store-operated Ca2+ entry coupled to large-conductance Ca2+-activated K+ channels in rat pinealocytes.
  • 13
  • PDF
...
1
2
3
4
5
...