TMEM16A alternative splicing coordination in breast cancer

@inproceedings{Ubby2013TMEM16AAS,
  title={TMEM16A alternative splicing coordination in breast cancer},
  author={Ifeoma Ubby and Erica Bussani and Antonio Colonna and Giuseppe Stacul and Martina Locatelli and Paolo Scudieri and Luis J. V. Galietta and Franco Pagani},
  booktitle={Molecular Cancer},
  year={2013}
}
TMEM16A, also known as Anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. The role of TMEM16A in cancer is not completely understood and no data are available regarding the potential tumorigenic properties of the multiple isoforms generated by alternative splicing (AS). We evaluated TMEM16A AS pattern, isoforms distribution and Splicing Coordination (SC), in normal tissues and breast cancers, through a semi-quantitative PCR-assay that amplifies transcripts… CONTINUE READING
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