TMEM16 proteins: unknown structure and confusing functions.

  title={TMEM16 proteins: unknown structure and confusing functions.},
  author={Alessandra Picollo and Mattia Malvezzi and Alessio Accardi},
  journal={Journal of molecular biology},
  volume={427 1},
The TMEM16 family of membrane proteins, also known as anoctamins, plays key roles in a variety of physiological functions that range from ion transport to phospholipid scrambling and to regulating other ion channels. The first two family members to be functionally characterized, TMEM16A (ANO1) and TMEM16B (ANO2), form Ca(2+)-activated Cl(-) channels and are important for transepithelial ion transport, olfaction, phototransduction, smooth muscle contraction, nociception, cell proliferation and… CONTINUE READING


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