TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.

@article{ChenPlotkin2012TMEM106BTR,
  title={TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.},
  author={Alice S Chen-Plotkin and Travis L. Unger and Michael D. Gallagher and Emily Bill and Linda K. Kwong and Laura A Volpicelli-Daley and Johanna Irene Busch and Sebastian Akle and Murray Grossman and Vivianna M Van Deerlin and John Q. Trojanowski and Virginia M-Y Lee},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 33},
  pages={11213-27}
}
Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is a fatal neurodegenerative disease with no available treatments. Mutations in the progranulin gene (GRN) causing impaired production or secretion of progranulin are a common Mendelian cause of FTLD-TDP; additionally, common variants at chromosome 7p21 in the uncharacterized gene TMEM106B were recently linked by genome-wide association to FTLD-TDP with and without GRN mutations. Here we show that TMEM106B is neuronally… CONTINUE READING
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