TMC-52A to D, novel cysteine proteinase inhibitors, produced by Gliocladium sp.

  title={TMC-52A to D, novel cysteine proteinase inhibitors, produced by Gliocladium sp.},
  author={Kengo Isshiki and Maki Nishio and Naoki Sakurai and Tomofumi Uchida and T{\^o}ru Okuda and Saburo Komatsubara},
  journal={The Journal of antibiotics},
  volume={51 7},
New cysteine proteinase inhibitors, TMC-52A, B, C, and D, were isolated from the fungal fermentation broth. On the basis of a taxonomical study, the producing strain, F-2665, was characterized as Gliocladium sp. Spectroscopic analyses and chemical degradation have shown TMC-52A to D to be epoxysuccinyl peptides. TMC-52A to D strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 values of 13 nM, 10nM, 10nM, and 6nM, respectively. 

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