TMC-52A to D, novel cysteine proteinase inhibitors, produced by Gliocladium sp.
@article{Isshiki1998TMC52ATD, title={TMC-52A to D, novel cysteine proteinase inhibitors, produced by Gliocladium sp.}, author={Kengo Isshiki and Maki Nishio and Naoki Sakurai and Tomofumi Uchida and T{\^o}ru Okuda and Saburo Komatsubara}, journal={The Journal of antibiotics}, year={1998}, volume={51 7}, pages={ 629-34 } }
New cysteine proteinase inhibitors, TMC-52A, B, C, and D, were isolated from the fungal fermentation broth. On the basis of a taxonomical study, the producing strain, F-2665, was characterized as Gliocladium sp. Spectroscopic analyses and chemical degradation have shown TMC-52A to D to be epoxysuccinyl peptides. TMC-52A to D strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 values of 13 nM, 10nM, 10nM, and 6nM, respectively.
9 Citations
TMC-171A,B,C and TMC-154, novel polyketide antibiotics produced by Gliocladium sp. TC 1304 and TC 1282.
- ChemistryThe Journal of antibiotics
- 1999
Four new antibiotics have been isolated from the fermentation of fungal strains Gliocladium sp.
WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp. I. Taxonomy, production, purification and structure elucidation.
- Biology, ChemistryThe Journal of antibiotics
- 1999
Spectroscopic analysis showed that WF 14861 consisted of trans-epoxysuccinic acid, L-tyrosine and spermidine, WF14861 inhibited cathepsins B and L selectively.
WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp. II. Biological properties.
- Biology, ChemistryThe Journal of antibiotics
- 1999
The compound ameliorated the tissue damage and the bone destruction models of low-calcium-diet-fed mouse and adjuvant arthritis rat model and showed inhibitory activities against bone derived crude protease and other cysteine proteases in vitro.
Aurantiamide Acetate, a Selective Cathepsin Inhibitor, Produced by Aspergillus penicilloides
- Biology, ChemistryBioscience, biotechnology, and biochemistry
- 2001
Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time and in the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.
(2S,3S)-Oxirane-2,3-dicarboxylic acid: a privileged platform for probing human cysteine cathepsins.
- BiologyJournal of biotechnology
- 2007
Biological Activities of Fungal Metabolites
- Biology
- 2005
The amazing range of chemical structures observed for fungal metabolites is derived from a relatively small number of basic metabolic pathways, plus combinations of these, which have become extremely diversified during the course of evolution.
International Journal of Current Research in
- Biology
- 2017
This review is a comprehensive survey of unique, unusual, and rare fatty acids incorporated into natural marine and terrestrial peptides obtained from fungi, fungal endophytes, lichenized…
6. Cathepsin K inhibitors: their potential as anti-osteoporosis agents.
- Biology, MedicineProgress in medicinal chemistry
- 2004
References
SHOWING 1-9 OF 9 REFERENCES
Isolation and characterization of new thiol protease inhibitors estatins A and B.
- Biology, ChemistryThe Journal of antibiotics
- 1989
New thiol protease inhibitors, estatins A and B, were isolated from the culture filtrate of Myceliophthora thermophila M4323 and suppressed IgE antibody production in mice, but not IgG.
Cathestatins, new cysteine protease inhibitors produced by Penicillium citrinum.
- Biology, ChemistryBioscience, biotechnology, and biochemistry
- 1995
New cysteine protease inhibitors, named cathestatin A and B, have been discovered as metabolites of Penicillium citrinum, which suppressed parathyroid hormone (PTH)-stimulated 45Ca release in organ cultures of chick embryonic calvaria.
Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity.
- Biology, ChemistryThe Journal of biological chemistry
- 1994
Studies on the optimum pH for the action of pepsin on "native" and denatured bovine serum albumin and bovine hemoglobin.
- BiologyThe Journal of biological chemistry
- 1959
A Dictionary of the Fungi
- MedicineNature
- 1943
A Dictionary of the FungiBy Dr. G. C. Ainsworth Dr. G. R. Bisby. Pp. viii + 360. (Kew: Imperial Mycological Institute, 1943.) 20s.
MIIKE (Meiji Seika Kaisha, LTD.): Production of PF1126A and B
- JPK
- 1995
ANDERSON: Compensium of soil fungi
- DOMSCH,
- 1980