TMC-2A, -2B and -2C, new dipeptidyl peptidase IV inhibitors produced by Aspergillus oryzae A374. II. Isolation and structure determination.

@article{Asai1997TMC2AA,
  title={TMC-2A, -2B and -2C, new dipeptidyl peptidase IV inhibitors produced by Aspergillus oryzae A374. II. Isolation and structure determination.},
  author={Yasuyuki Asai and Nobuaki Nonaka and Maki Nishio and Kazuhiko Okamura and Tadamasa Date and Takuo Sugita and Takashi Ohnuki and Saburo Komatsubara},
  journal={The Journal of antibiotics},
  year={1997},
  volume={50 8},
  pages={653-8}
}
New dipeptidyl peptidase IV inhibitors, TMC-2A, -2B, and -2C, were isolated from the fermentation broth of Aspergillus oryzae A374. On the basis of chemical, spectroscopic and X-ray crystallographic analyses, their structures were established to be peptide-like compounds composed of three moieties, L-tryptophan, mono- or dihydroxy-L-leucine and highly substituted isoquinoline. 

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