TMC-135A and B, new triene-ansamycins, produced by Streptomyces sp.

  title={TMC-135A and B, new triene-ansamycins, produced by Streptomyces sp.},
  author={Maki Nishio and Jun Kohno and Masaaki Sakurai and S Suzuki and N Okada and Kimio Kawano and Saburo Komatsubara},
  journal={The Journal of antibiotics},
  volume={53 7},
closely related to thiazinotrienomycins and cytotrienins1 ^. This paper briefly describes the taxonomy, isolation, physico-chemical properties, structure elucidation and biological activity ofTMC-135A and B. The producing strain TC 1190 was isolated from a soil sample. The substrate mycelium developed well and branched irregularly. Each spore chain, which was spiral type, had 20 to 50 or more spores per chain. The spores were cylindrical, with size of 0.5-0.8X0.6-0.9^m, and 
TMC-69, a new antitumor antibiotic with Cdc25A inhibitory activity, produced by Chrysosporium sp. TC1068. Taxonomy, fermentation and biological activities.
A new antibiotic designated TMC-69 has been isolated from, the fermentation broth of a fungal strain Chrysosporium sp. TC 1068. TMC-69 exhibited moderate in vitro cytotoxic activity. TMC-69-6H, aExpand
Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.
Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. TheExpand
Thiazinogeldanamycin, a new geldanamycin derivative produced by Streptomyces hygroscopicus 17997.
Thiazinogeldanamycin may represent the first natural GDM derivative characterized so far that uses GDM as its precursor, and clearly indicates that an appropriate end-point of fermentation is of critical importance for the maximal production of GDM by Streptomyces hygroscopicus 17997. Expand
Sequences of Acretocins, Peptaibiotics Containing the Rare 1‐Aminocyclopropanecarboxylic Acid, from Acremonium crotocinigenum CBS 217.70
Seven non-ribosomal polypeptide antibiotics, named acretocins (ACRs), were obtained from Acremonium crotocinigenum strain CBS 217.70 and show in part sequence identity with neoefrapeptins. Expand
Alkaloids from the sponge-associated fungus aspergillus sp.
Seven new alkaloids including tryptoquivaline K (1) and fumiquinazolines K–P (2–7), bearing a rare 1-aminocyclopropane-1-carboxylic acid residue, together with six known compounds (8–13), wereExpand
Production of heptaene antifungal antibiotic by Streptomyces purpeofuscus CM 1261.
  • P. Jain, P. Jain
  • Medicine, Biology
  • Indian journal of experimental biology
  • 2005
A strain of Streptomyces purpeofuscus CM 1261 isolated from a sample of compost collected locally was found to possess strong antagonistic activity against 4 human pathogenic fungi i.e., CandidaExpand
Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp.
The structure of Trierixin is elucidated as 21-thiomethylmycotrienin II, a new member of the triene-ansamycin group isolated from the fermentation broth of Streptomyces sp. Expand
Design and synthesis of ansamycin antibiotics
This review covers the synthetic chemistry and biological activity of benzenic ansamycins from 1989 to 2007 and synthetic approaches to the C15-benzene ans Amycins (geldanamycin and related) are discussed. Expand
Selective isolation and distribution of the genus Planomonospora in soils.
Strains of P. venezuelensis group were obtained from 13 soil samples collected in Bolivia, Cyprus, Egypt, Greece, India, Japan, New Caledonia, and Turkey, the first record that strains of this group have been isolated from a location other than Venezuela. Expand
SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation
Four novel triene-ansamycin group compounds were isolated from the culture broth of Streptomyces sp. Expand


Thiazinotrienomycins, new ansamycin group antibiotics.
New triene-ansamycins designated thiazinotrienomycins A, B, C, D and E were isolated from culture broth of Streptomyces sp. MJ672-m3 for their activities against cervical cancer cell lines. TheExpand
Effect of thiazinotrienomycin B, an ansamycin antibiotic, on the function of epidermal growth factor receptor in human stomach tumor cells.
Thiazinotrienomycin B and anti-epidermal growth factor receptor (anti-EGFR) were antagonistic to each other in inhibiting the cell cycle progression of SC-6 from G0/G1 to S, suggesting that the two compounds share the same target, EGFR. Expand
Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells.
New apoptosis inducers derived from microorganisms are explored by utilizing a human promyelocytic leukaemia cell line, HL-60 as an indicator of apoptosis, and it is found that an actinomycete strain RK95-74 isolated from a soil sample collected in Shiki City, Saitama Prefecture, Japan, produced a new potent apoptosis inducer. Expand
Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis.
Results indicate that p36 MBP kinase activation is downstream of the activation of Z-Asp-CH2-DCB-sensitive caspases, and reactive oxygen species could be included in the apoptotic events. Expand
TMC-1 A, B, C and D, new antibiotics of the manumycin group produced by Streptomyces sp. Taxonomy, production, isolation, physico-chemical properties, structure elucidation and biological properties.
Four new antitumor antibiotics, TMC-1 A, B, C and D were isolated from a fermentation broth of Streptomyces sp. A-230. Spectroscopic studies have shown that TMC-1 A to D were new members of theExpand