TMBIM protein family: ancestral regulators of cell death

  title={TMBIM protein family: ancestral regulators of cell death},
  author={Diego Rojas-Rivera and Claudio Hetz},
The control of apoptosis in mammals has been historically associated with the activity of the BCL-2 family of proteins at the mitochondria. In the past years, a novel group of cell death regulators have emerged, known as the Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) protein family. This group of proteins is composed of at least six highly conserved members expressed in mammals, with homologs in insects, fish, plants, viruses and yeast. Different studies indicate that all TMBIM… CONTINUE READING
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