TM9SF4 levels determine sorting of transmembrane domains in the early secretory pathway

@article{Vernay2018TM9SF4LD,
  title={TM9SF4 levels determine sorting of transmembrane domains in the early secretory pathway},
  author={Alexandre Vernay and O. Lamrabet and J. Perrin and P. Cosson},
  journal={Journal of Cell Science},
  year={2018},
  volume={131}
}
  • Alexandre Vernay, O. Lamrabet, +1 author P. Cosson
  • Published 2018
  • Biology, Medicine
  • Journal of Cell Science
    • ABSTRACT Previous studies have shown that TM9SF4 interacts with glycine-rich transmembrane domains (TMDs) and promotes their surface localization, presumably by escorting them along the secretory pathway. Here, we delineated the role of TM9 proteins in the sorting of TMDs. Our results indicate that TM9SF4 interacts with and sorts a variety of TMDs. In human embryonic kidney (HEK) cells, a TMD carrying a positively charged residue (T-R1) or a negatively charged residue (T-D1) was localized to… CONTINUE READING
    View on Publisher
    jcs.biologists.org

    Figures and Topics from this paper

    Figures

    Explore Further: Topics Discussed in This Paper

    References

    SHOWING 1-10 OF 26 REFERENCES
    TM9 family proteins control surface targeting of glycine-rich transmembrane domains
    • 12
    • PDF
    Targeting to the Endoplasmic Reticulum in Yeast Cells by Determinants Present in Transmembrane Domains*
    • 60
    • PDF
    Control of Cellular Physiology by TM9 Proteins in Yeast and Dictyostelium*
    • 24
    • PDF
    A Comprehensive Comparison of Transmembrane Domains Reveals Organelle-Specific Properties
    • 376
    • PDF
    Signal-mediated sorting of membrane proteins between the endoplasmic reticulum and the golgi apparatus.
    • 522
    Erv14p directs a transmembrane secretory protein into COPII-coated transport vesicles.
    • 112
    • PDF
    Anchors aweigh: protein localization and transport mediated by transmembrane domains
    • 41
    Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells
    • 11
    • PDF
    Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum.
    • 188
    Synergistic control of cellular adhesion by transmembrane 9 proteins.
    • 48
    • PDF