TM9SF4 levels determine sorting of transmembrane domains in the early secretory pathway

  title={TM9SF4 levels determine sorting of transmembrane domains in the early secretory pathway},
  author={Alexandre Vernay and O. Lamrabet and J. Perrin and P. Cosson},
  journal={Journal of Cell Science},
  • Alexandre Vernay, O. Lamrabet, +1 author P. Cosson
  • Published 2018
  • Biology, Medicine
  • Journal of Cell Science
  • ABSTRACT Previous studies have shown that TM9SF4 interacts with glycine-rich transmembrane domains (TMDs) and promotes their surface localization, presumably by escorting them along the secretory pathway. Here, we delineated the role of TM9 proteins in the sorting of TMDs. Our results indicate that TM9SF4 interacts with and sorts a variety of TMDs. In human embryonic kidney (HEK) cells, a TMD carrying a positively charged residue (T-R1) or a negatively charged residue (T-D1) was localized to… CONTINUE READING

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