TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141

@inproceedings{Xue2017TM4SF1PT,
  title={TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141},
  author={Lei Xue and Xiying Yu and Xingran Jiang and Xin Deng and Linlin Mao and Liping Guo and Jinhu Fan and Qinqxia Fan and Liuxing Wang and Shixin Lu},
  booktitle={Oncotarget},
  year={2017}
}
Cancer stem-like cells have been identified in primary human tumors and cancer cell lines. Previously we found TM4SF1 gene was highly expressed in side population (SP) cells from esophageal squamous cell carcinoma (ESCC) cell lines, but the role and underlying mechanism of TM4SF1 in ESCC remain unclear. In this study, we observed TM4SF1 was up-regulated but miR-141 was down-regulated in SP cells isolated from ESCC cell lines. TM4SF1 could stimulate the self-renewal ability and carcinogenicity… CONTINUE READING