TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141
@article{Xue2017TM4SF1PT, title={TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141}, author={Lei Xue and Xiying Yu and Xingran Jiang and X. Deng and Linlin Mao and L. Guo and J. Fan and Q. Fan and L. Wang and S. Lu}, journal={Oncotarget}, year={2017}, volume={8}, pages={19274 - 19284} }
Cancer stem-like cells have been identified in primary human tumors and cancer cell lines. Previously we found TM4SF1 gene was highly expressed in side population (SP) cells from esophageal squamous cell carcinoma (ESCC) cell lines, but the role and underlying mechanism of TM4SF1 in ESCC remain unclear. In this study, we observed TM4SF1 was up-regulated but miR-141 was down-regulated in SP cells isolated from ESCC cell lines. TM4SF1 could stimulate the self-renewal ability and carcinogenicity… CONTINUE READING
17 Citations
DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells
- Medicine
- Oncotarget
- 2018
- 7
- PDF
miR-30 Family Reduction Maintains Self-Renewal and Promotes Tumorigenesis in NSCLC-Initiating Cells by Targeting Oncogene TM4SF1.
- Biology, Medicine
- Molecular therapy : the journal of the American Society of Gene Therapy
- 2018
- 12
LOC441178 Overexpression Inhibits the Proliferation and Migration of Esophageal Carcinoma Cells via Methylation of miR-182
- Chemistry, Medicine
- OncoTargets and therapy
- 2020
- PDF
Lost miR-141 and upregulated TM4SF1 expressions associate with poor prognosis of pancreatic cancer: regulation of EMT and angiogenesis by miR-141 and TM4SF1 via AKT
- Medicine
- Cancer biology & therapy
- 2020
- 4
Osteopontin production by TM4SF4 signaling drives a positive feedback autocrine loop with the STAT3 pathway to maintain cancer stem cell-like properties in lung cancer cells
- Biology, Medicine
- Oncotarget
- 2017
- 19
- PDF
microRNA-520f inhibits hepatocellular carcinoma cell proliferation and invasion by targeting TM4SF1.
- Biology, Medicine
- Gene
- 2018
- 11
TM4SF1 is a potential target for anti-invasion and metastasis in ovarian cancer
- Biology, Medicine
- BMC Cancer
- 2019
- 6
Expression of miRNA in 5-FU resistant esophageal cancer.
- Biology, Medicine
- Molecular and clinical oncology
- 2020
- PDF
TM4SF1, a binding protein of DVL2 in hepatocellular carcinoma, positively regulates beta-catenin/TCF signalling.
- Chemistry, Medicine
- Journal of cellular and molecular medicine
- 2019
- 4
References
SHOWING 1-10 OF 51 REFERENCES
miR-203 inhibits the proliferation and self-renewal of esophageal cancer stem-like cells by suppressing stem renewal factor Bmi-1.
- Biology, Medicine
- Stem cells and development
- 2014
- 78
The PTEN/PI3K/Akt pathway regulates stem-like cells in primary esophageal carcinoma cells
- Biology, Medicine
- Cancer biology & therapy
- 2011
- 67
- Highly Influential
hsa-miR-141 downregulates TM4SF1 to inhibit pancreatic cancer cell invasion and migration.
- Biology, Medicine
- International journal of oncology
- 2014
- 62
- PDF
Isolation and identification of cancer stem-like cells in esophageal carcinoma cell lines.
- Biology, Medicine
- Stem cells and development
- 2009
- 141
- Highly Influential
TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells.
- Biology, Medicine
- International journal of oncology
- 2015
- 13
- PDF
Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells
- Biology, Medicine
- Cell
- 2009
- 1,083
- PDF
Down-regulation of miR-141 in gastric cancer and its involvement in cell growth
- Medicine
- Journal of Gastroenterology
- 2009
- 179
Tumor-associated antigen L6 and the invasion of human lung cancer cells.
- Biology, Medicine
- Clinical cancer research : an official journal of the American Association for Cancer Research
- 2003
- 72
- PDF
microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network.
- Biology, Medicine
- Carcinogenesis
- 2010
- 146
- PDF
Characterization of side population in thyroid cancer cell lines: cancer stem-like cells are enriched partly but not exclusively.
- Biology, Medicine
- Endocrinology
- 2007
- 232
- PDF