TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141

@article{Xue2017TM4SF1PT,
  title={TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141},
  author={Lei Xue and Xiying Yu and Xingran Jiang and X. Deng and Linlin Mao and L. Guo and J. Fan and Q. Fan and L. Wang and S. Lu},
  journal={Oncotarget},
  year={2017},
  volume={8},
  pages={19274 - 19284}
}
  • Lei Xue, Xiying Yu, +7 authors S. Lu
  • Published 2017
  • Medicine
  • Oncotarget
  • Cancer stem-like cells have been identified in primary human tumors and cancer cell lines. Previously we found TM4SF1 gene was highly expressed in side population (SP) cells from esophageal squamous cell carcinoma (ESCC) cell lines, but the role and underlying mechanism of TM4SF1 in ESCC remain unclear. In this study, we observed TM4SF1 was up-regulated but miR-141 was down-regulated in SP cells isolated from ESCC cell lines. TM4SF1 could stimulate the self-renewal ability and carcinogenicity… CONTINUE READING
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    References

    SHOWING 1-10 OF 51 REFERENCES
    miR-203 inhibits the proliferation and self-renewal of esophageal cancer stem-like cells by suppressing stem renewal factor Bmi-1.
    • 78
    The PTEN/PI3K/Akt pathway regulates stem-like cells in primary esophageal carcinoma cells
    • 67
    • Highly Influential
    hsa-miR-141 downregulates TM4SF1 to inhibit pancreatic cancer cell invasion and migration.
    • L. Xu, Q. Li, +6 authors Y. Miao
    • Biology, Medicine
    • International journal of oncology
    • 2014
    • 62
    • PDF
    Isolation and identification of cancer stem-like cells in esophageal carcinoma cell lines.
    • 141
    • Highly Influential
    TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells.
    • 13
    • PDF
    Down-regulation of miR-141 in gastric cancer and its involvement in cell growth
    • 179
    Tumor-associated antigen L6 and the invasion of human lung cancer cells.
    • 72
    • PDF
    microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network.
    • 146
    • PDF