TLS inhibits RNA polymerase III transcription.

  title={TLS inhibits RNA polymerase III transcription.},
  author={Adelene Y Tan and James L Manley},
  journal={Molecular and cellular biology},
  volume={30 1},
RNA transcription by all the three RNA polymerases (RNAPs) is tightly controlled, and loss of regulation can lead to, for example, cellular transformation and cancer. While most transcription factors act specifically with one polymerase, a small number have been shown to affect more than one polymerase to coordinate overall levels of transcription in cells. Here we show that TLS (translocated in liposarcoma), a protein originally identified as the product of a chromosomal translocation and… CONTINUE READING
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