TLRs control hematopoiesis during infection.

  title={TLRs control hematopoiesis during infection.},
  author={Alberto Y{\'a}{\~n}ez and Helen S. Goodridge and Daniel Gozalbo and Mar{\'i}a Luisa Mal{\'e} Gil},
  journal={European journal of immunology},
  volume={43 10},
Recent research has shown that (i) Toll-like receptor (TLR) agonists drive hematopoietic stem and progenitor cells (HSPCs) to proliferate and differentiate along the myeloid lineage in vitro, and (ii) direct TLR-mediated stimulation of HSPCs also promotes macrophage differentiation in vivo following infection. These new insights demonstrate that TLR signaling in HSPCs, in addition to other TLR-dependent mechanisms, can contribute to HSPC expansion and myeloid differentiation after infection… CONTINUE READING