TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia.

@article{ScharfeNugent2012TLR9PI,
  title={TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia.},
  author={Andrea Scharfe-Nugent and Sin{\'e}ad C. Corr and Susan B. Carpenter and Louise A Keogh and Brendan Doyle and Cara Martin and Katherine A. Fitzgerald and Sean Daly and John J O'leary and Luke A J O'Neill},
  journal={Journal of immunology},
  year={2012},
  volume={188 11},
  pages={5706-12}
}
Preterm birth, the major cause of neonatal mortality in developed countries, is associated with intrauterine infections and inflammation, although the exact mechanisms underlying this event are unclear. In this study, we show that circulating fetal DNA, which is elevated in pregnancies complicated by preterm labor or preeclampsia, triggers an inflammatory reaction that results in spontaneous preterm birth. Fetal DNA activates NF-κB, shown by IκBα degradation in human PBMCs resulting in… CONTINUE READING
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Role of fetal DNA in preeclampsia (review).

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