TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis.

@article{Bhan2013TLR9dependentII,
  title={TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis.},
  author={Urvashi Bhan and Michael J. Newstead and Xianying Zeng and Amy Podsaid and Moloy T. Goswami and Megan N. Ballinger and Steven L. Kunkel and Theodore J Standiford},
  journal={Journal of immunology},
  year={2013},
  volume={190 1},
  pages={349-56}
}
Hypersensitivity pneumonitis (HP) is an inflammatory lung disease that develops after repeated exposure to inhaled particulate Ag. Stachybotrys chartarum is a dimorphic fungus that has been implicated in a number of respiratory illnesses, including HP. In this study, we have developed a murine model of S. chartarum-induced HP that reproduces pathology observed in human HP, and we have hypothesized that TLR9-mediated IL-23 and IL-17 responses are required for the generation of granulomatous… CONTINUE READING