TLR9-Targeted SiRNA Delivery In Vivo.

  title={TLR9-Targeted SiRNA Delivery In Vivo.},
  author={Dewan Md Sakib Hossain and Dayson Moreira and Qifang Zhang and Sergey Nechaev and Piotr M Swiderski and Marcin Kortylewski},
  journal={Methods in molecular biology},
The SiRNA strategy is a potent and versatile method for modulating expression of any gene in various species for investigational or therapeutic purposes. Clinical translation of SiRNA-based approaches proved challenging, mainly due to the difficulty of targeted SiRNA delivery into cells of interest and the immunogenic side effects of oligonucleotide… CONTINUE READING