TLR9 Agonist Protects Mice from Radiation-Induced Gastrointestinal Syndrome

Abstract

PURPOSE Radiation-induced gastrointestinal syndrome (RIGS) is due to the clonogenic loss of crypt cells and villi depopulation, resulting in disruption of mucosal barrier, bacterial invasion, inflammation and sepsis. Intestinal macrophages could recognize invading bacterial DNA via TLR9 receptors and transmit regenerative signals to the neighboring crypt… (More)
DOI: 10.1371/journal.pone.0029357

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Cite this paper

@inproceedings{Saha2012TLR9AP, title={TLR9 Agonist Protects Mice from Radiation-Induced Gastrointestinal Syndrome}, author={Subhrajit K. Saha and Payel Bhanja and Laibin Liu and Alan A. Alfieri and Dong Yu and Ekambar R. Kandimalla and Sudhir Agrawal and Chandan Guha}, booktitle={PloS one}, year={2012} }