TLR8 deficiency leads to autoimmunity in mice.

  title={TLR8 deficiency leads to autoimmunity in mice.},
  author={Olivier Demaria and Philippe P. Pagni and Stephanie Traub and Aude De Gassart and Nora Branzk and Andrew J. Murphy and David M. Valenzuela and George D. Yancopoulos and Richard A Flavell and Lena Alexopoulou},
  journal={The Journal of clinical investigation},
  volume={120 10},
TLRs play an essential role in the induction of immune responses by detecting conserved molecular products of microorganisms. However, the function of TLR8 is largely unknown. In the current study, we investigated the role of TLR8 signaling in immunity in mice. We found that Tlr8(-/-) DCs overexpressed TLR7, were hyperresponsive to various TLR7 ligands, and showed stronger and faster NF-κB activation upon stimulation with the TLR7 ligand R848. Tlr8(-/-) mice showed splenomegaly, defective… CONTINUE READING


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