TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes.

@article{Eigenbrod2015TLR8SB,
  title={TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes.},
  author={Tatjana Eigenbrod and Karin Pelka and Eicke Latz and Bernd Kreikemeyer and Alexander H Dalpke},
  journal={Journal of immunology},
  year={2015},
  volume={195 3},
  pages={1092-9}
}
Microbial nucleic acids constitute an important group of pathogen-associated molecular patterns (PAMPs) that efficiently trigger innate immune activation. In mice, TLR13 has recently been identified to sense a highly conserved region within bacterial 23S rRNA. However, TLR13 is not expressed in humans, and the identity of its human homolog remains elusive. Moreover, the contribution of bacterial RNA to the induction of innate immune responses against entire bacteria is still insufficiently… CONTINUE READING