TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation.

@article{Larang2009TLR7AT,
  title={TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation.},
  author={Alexandre Larang{\'e} and Diane Antonios and Marc Pallardy and Saadia Kerdine-Roemer},
  journal={Journal of leukocyte biology},
  year={2009},
  volume={85 4},
  pages={673-83}
}
Dendritic cells (DCs) play an important role in bridging innate and adaptive immunity. These APCs have the ability to recognize specific molecular signatures of pathogens through TLRs. In particular, the intracellular TLR7 and TLR8, mediating the recognition of ssRNA by DCs, play a major role in the immune response during viral infection. Although… CONTINUE READING