TLR7 and 9 agonists are highly effective mucosal adjuvants for norovirus virus-like particle vaccines.

@article{Hjelm2014TLR7A9,
  title={TLR7 and 9 agonists are highly effective mucosal adjuvants for norovirus virus-like particle vaccines.},
  author={Brooke E. Hjelm and Jacquelyn A. Kilbourne and Melissa M Herbst-Kralovetz},
  journal={Human vaccines & immunotherapeutics},
  year={2014},
  volume={10 2},
  pages={410-6}
}
Virus-like particles (VLPs) are an active area of vaccine research, development and commercialization. Mucosal administration of VLPs provides an attractive avenue for delivery of vaccines with the potential to produce robust immune responses. Nasal and oral delivery routes are particularly intriguing due to differential activation of mucosa-associated lymphoid tissues. We compared both intranasal and oral administration of VLPs with a panel of toll-like receptor (TLR) agonists (TLR3, 5, 7, 7/8… CONTINUE READING