TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

@article{Rodell2018TLR78agonistloadedNP,
  title={TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy},
  author={Christopher Blake Rodell and Sean Philip Arlauckas and Michael F. Cuccarese and Christopher S. Garris and Ran Li and Maaz S. Ahmed and Rainer H. Kohler and Mikael J. Pittet and Ralph Weissleder},
  journal={Nature Biomedical Engineering},
  year={2018},
  volume={2},
  pages={578-588}
}
Tumour-associated macrophages are abundant in many cancers, and often display an immune-suppressive M2-like phenotype that fosters tumour growth and promotes resistance to therapy. [] Key Result As a monotherapy, the administration of CDNP-R848 in multiple tumour models in mice altered the functional orientation of the tumour immune microenvironment towards an M1 phenotype, leading to controlled tumour growth and protecting the animals against tumour rechallenge.

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Macrophage Reprogramming with Anti-miR223-Loaded Artificial Protocells Enhances In Vivo Cancer Therapeutic Potential.

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