TLR7, IFNγ, and T-bet: their roles in the development of ABCs in female-biased autoimmunity.

@article{Rubtsova2015TLR7IA,
  title={TLR7, IFNγ, and T-bet: their roles in the development of ABCs in female-biased autoimmunity.},
  author={K. V. Rubtsova and Philippa Marrack and Anatoly V. Rubtsov},
  journal={Cellular immunology},
  year={2015},
  volume={294 2},
  pages={
          80-3
        }
}
The majority of autoimmune diseases have a strong gender bias, affecting mostly females. Gender-specific factors like sex-hormones, the presence or absence of a second X chromosome, and gender-specific gut microbiota may contribute to this bias. In this review we will discuss the role of the X chromosome encoded toll-like receptor 7 (TLR7) and interferon gamma (IFNγ) in the development of autoimmunity. We will also review recent data indicating how these factors may affect an immune response in… CONTINUE READING
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