TLR4 through IFN-β promotes low molecular mass hyaluronan-induced neutrophil apoptosis.

Abstract

Intratracheal administration of low molecular mass (LMM) hyaluronan (200 kDa) results in greater neutrophil infiltration in the lungs of TLR4(-/-) mice compared with that in wild-type mice. In general, enhanced neutrophil infiltration in tissue is due to cell influx; however, neutrophil apoptosis also plays an important role. We have assessed the effects of… (More)
DOI: 10.4049/jimmunol.1001630

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