TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells.

@article{Qian2008TLR4SI,
  title={TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells.},
  author={Yigang Qian and Junfang Deng and Lei Geng and Hai-Yang Xie and Guoping Jiang and Lin Zhou and Ming Sheng Zhang and Shenyong Yin and Xiaowen Feng and Junwei Liu and Zhou Jing Ye and Shusen Zheng},
  journal={Cancer investigation},
  year={2008},
  volume={26 8},
  pages={
          816-21
        }
}
TLR4 (Toll-like receptor 4) and B7-H1, which were known to be restricted to immune cells in the past, were found to be aberrantly expressed in a majority of tumor cells, facilitating tumor evasion from immune surveillance. Our study demonstrated that activation of TLR4 signaling in bladder cancer cells up-regulated B7-H1 expression. Furthermore, this regulation was significantly attenuated by ERK or JNK inhibitor. Our results elucidated the molecule mechanism of regulation of B7-H1 expression… CONTINUE READING
BETA

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 40 CITATIONS

Recent Findings in the Regulation of Programmed Death Ligand 1 Expression

Xiangfeng Shen, Lihong Zhang, +3 authors Zhi-Xiang Xu
  • Front. Immunol.
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer

  • Medical science monitor : international medical journal of experimental and clinical research
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

Regulatory mechanisms of PD-L1 expression in cancer cells

  • Cancer Immunology, Immunotherapy
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND