TLR4 signaling-induced heme oxygenase upregulation in the acute lung injury: role in hemorrhagic shock and two-hit induced lung inflammation

@article{Chen2012TLR4SH,
  title={TLR4 signaling-induced heme oxygenase upregulation in the acute lung injury: role in hemorrhagic shock and two-hit induced lung inflammation},
  author={Chang Chen and Fan Zhang and Zongze Zhang and Mian Peng and Yanlin Wang and Ying-Ying Chen},
  journal={Molecular Biology Reports},
  year={2012},
  volume={40},
  pages={1167-1172}
}
Resuscitated hemorrhagic shock is believed to promote the development of acute lung injury (ALI) by priming the immune system for an exaggerated inflammatory response to a second trivial stimulus. This work explored effects of TLR4 on hemorrhage-induced ALI and “second-hit” responses, and further explore the mechanisms involved in “second-hit” responses. Expression of HO-1, IL-10, lung W/D and MPO markedly increased at nearly all time-points examined in HSR/LPS group as compared with sham/LPS… CONTINUE READING

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