TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice.

@article{GonzlezNavajas2010TLR4SI,
  title={TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice.},
  author={Jos{\'e} Manuel Gonz{\'a}lez-Navajas and Sean D Fine and Jason Law and Sandip K Datta and Kim P Nguyen and Mandy Wai Man Yu and Maripat Corr and Kyoko Katakura and Lars Eckman and J. Scott Lee and Eyal Raz},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 2},
  pages={570-81}
}
TLRs sense various microbial products. Their function has been best characterized in DCs and macrophages, where they act as important mediators of innate immunity. TLR4 is also expressed on CD4+ T cells, but its physiological function on these cells remains unknown. Here, we have shown that TLR4 triggering on CD4+ T cells affects their phenotype and their ability to provoke intestinal inflammation. In a model of spontaneous colitis, Il10-/-Tlr4-/- mice displayed accelerated development of… CONTINUE READING
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Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in il-10-deficient mice. Gastroenterology

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