TLR4 signaling attenuates ongoing allergic inflammation.

  title={TLR4 signaling attenuates ongoing allergic inflammation.},
  author={John W. Hollingsworth and Gregory S. Whitehead and Kaifeng Lisa Lin and Hideki Nakano and Michael D Gunn and David A Schwartz and Donald N. Cook},
  journal={Journal of immunology},
  volume={176 10},
The relationship between LPS exposure and allergic asthma is poorly understood. Epidemiologic studies in humans have found that exposure to LPS can protect, have no effect, or exacerbate allergic asthma. Similarly, LPS has had variable effects on allergic pulmonary inflammation in the mouse, depending on the model used. In the present study, we studied the effect of very low doses of LPS in models of both short-term and long-term allergen challenge. When challenged with allergen for short… CONTINUE READING
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