TLR4 signal transduction pathways neutralize the effect of Fas signals on glioblastoma cell proliferation and migration.

@article{Sarrazy2011TLR4ST,
  title={TLR4 signal transduction pathways neutralize the effect of Fas signals on glioblastoma cell proliferation and migration.},
  author={Vincent Sarrazy and Nicolas V{\'e}drenne and Fabrice Billet and Nelly Bordeau and S{\'e}bastien Lepreux and Anne Vital and Marie-Odile Jauberteau and Alexis Desmouli{\`e}re},
  journal={Cancer letters},
  year={2011},
  volume={311 2},
  pages={
          195-202
        }
}
The Fas pathway is described as an activator of the glioblastoma proliferation by increasing the pathogenicity of this tumour. The lipopolysaccharide (LPS) pathway depending on Toll-like receptor 4 (TLR4) could limit the glioblastoma spreading. Here, Fas and TLR4 pathways were activated in glioblastoma cell lines by an agonist antibody and/or LPS treatment. Activation of the Fas pathway or of the TLR4 pathway induced cell proliferation. However, simultaneous treatment with agonist antibody and… CONTINUE READING
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