TLR4 signal transduction pathways neutralize the effect of Fas signals on glioblastoma cell proliferation and migration.


The Fas pathway is described as an activator of the glioblastoma proliferation by increasing the pathogenicity of this tumour. The lipopolysaccharide (LPS) pathway depending on Toll-like receptor 4 (TLR4) could limit the glioblastoma spreading. Here, Fas and TLR4 pathways were activated in glioblastoma cell lines by an agonist antibody and/or LPS treatment… (More)
DOI: 10.1016/j.canlet.2011.07.018


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