TLR4 mediates LPS-induced VEGF expression in odontoblasts.

  title={TLR4 mediates LPS-induced VEGF expression in odontoblasts.},
  author={Tatiana M Botero and Charles E. Shelburne and G. Holland and Carl Thomas Hanks and Jacques Eduardo N{\"o}r},
  journal={Journal of endodontics},
  volume={32 10},
Lipopolysaccharide (LPS) from gram-negative bacteria cell walls such as Prevotella intermedia and Escherichia coli induce vascular endothelial growth factor (VEGF) expression in odontoblasts, but not in undifferentiated dental pulp cells. CD14 and TLR4 are responsible for LPS signaling in macrophages, but their expression levels and function in dental pulp cells are unknown. We showed here that murine odontoblast-like cells (MDPC-23) express CD14 and TLR4 by immunohistochemistry and flow… CONTINUE READING

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