TLR4-mediated sensing of Campylobacter jejuni by dendritic cells is determined by sialylation.

  title={TLR4-mediated sensing of Campylobacter jejuni by dendritic cells is determined by sialylation.},
  author={Mark Kuijf and Janneke N. Samsom and Wouter van Rijs and Marieke Bax and Ruth Huizinga and Astrid P. Heikema and Pieter Antoon van Doorn and Alex van Belkum and Yvette van Kooyk and Peter C. Burgers and Theo M. Luider and Hubert Ph Endtz and Edward E. S. Nieuwenhuis and Bart Casper Jacobs},
  journal={Journal of immunology},
  volume={185 1},
In Guillain-Barré syndrome (GBS), ganglioside mimicry of Campylobacter jejuni lipo-oligosaccharide (LOS) drives the production of cross-reactive Abs to peripheral nerve gangliosides. We determined whether sialic acid residues in C. jejuni LOS modulate dendritic cell (DC) activation and subsequent B cell proliferation as a possible mechanism for the aberrant humoral immune response in GBS. Highly purified sialylated LOS of C. jejuni isolates from three GBS patients induced human DC maturation… CONTINUE READING


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