TLR4-mediated sensing of Campylobacter jejuni by dendritic cells is determined by sialylation.

@article{Kuijf2010TLR4mediatedSO,
  title={TLR4-mediated sensing of Campylobacter jejuni by dendritic cells is determined by sialylation.},
  author={Mark Kuijf and Janneke N. Samsom and Wouter van Rijs and Marieke Bax and Ruth Huizinga and Astrid P. Heikema and Pieter Antoon van Doorn and Alex van Belkum and Yvette van Kooyk and Peter C. Burgers and Theo M. Luider and Hubert Ph Endtz and Edward E. S. Nieuwenhuis and Bart Casper Jacobs},
  journal={Journal of immunology},
  year={2010},
  volume={185 1},
  pages={748-55}
}
In Guillain-Barré syndrome (GBS), ganglioside mimicry of Campylobacter jejuni lipo-oligosaccharide (LOS) drives the production of cross-reactive Abs to peripheral nerve gangliosides. We determined whether sialic acid residues in C. jejuni LOS modulate dendritic cell (DC) activation and subsequent B cell proliferation as a possible mechanism for the aberrant humoral immune response in GBS. Highly purified sialylated LOS of C. jejuni isolates from three GBS patients induced human DC maturation… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 39 references

Dendritic Cells Enhance Growth and Differentiation of CD40-activated B Lymphocytes

The Journal of experimental medicine • 1997
View 11 Excerpts
Highly Influenced

Axonal Guillain-Barré syndrome: carbohydrate mimicry and pathophysiology.

Journal of the peripheral nervous system : JPNS • 2007
View 4 Excerpts
Highly Influenced

Validation of an ELISA for the diagnosis of recent Campylobacter infections in Guillain-Barré and reactive arthritis patients.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases • 2007

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