TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS.

@article{Zeuke2002TLR4mediatedIA,
  title={TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS.},
  author={Stefanie Zeuke and Artur J. Ulmer and Shoichi Kusumoto and Hugo A. Katus and Holger Heine},
  journal={Cardiovascular research},
  year={2002},
  volume={56 1},
  pages={126-34}
}
OBJECTIVE Blood levels of cytokines are commonly elevated in severe congestive heart failure (CHF) and in coronary artery disease (CAD). While the adverse effects of cytokines on contractile function and myocardial cell integrity are well studied, little is known on whether cardiac cells are only targets or active players in these inflammatory reactions. METHODS AND RESULTS We tested if human coronary artery endothelial cells (HCAEC) may become a source of cytokine and adhesion molecule… CONTINUE READING