TLR4-dependent activation of inflammatory cytokine response in macrophages by Francisella elongation factor Tu.

@article{Sharma2011TLR4dependentAO,
  title={TLR4-dependent activation of inflammatory cytokine response in macrophages by Francisella elongation factor Tu.},
  author={Jyotika Sharma and Bibhuti Bhusan Mishra and Qun Li and Jennifer Teale},
  journal={Cellular immunology},
  year={2011},
  volume={269 2},
  pages={
          69-73
        }
}
The bacterial determinants of pulmonary Francisella induced inflammatory responses and their interaction with host components are not clearly defined. In this study, proteomic and immunoblot analyses showed presence of a cytoplasmic protein elongation factor Tu (EF-Tu) in the membrane fractions of virulent Francisella novicida, LVS and SchuS4, but not in an attenuated F. novicida mutant. EF-Tu was immunodominant in mice vaccinated and protected from virulent F. novicida. Moreover, recombinant… CONTINUE READING
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