TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant

@article{Saenz2014TLR4dependentAO,
  title={TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant},
  author={R. Saenz and D. Futalan and Lien Leutenez and Fien Eekhout and Jessie-F. Fecteau and Simeon Sundelius and Stig Sundqvist and M. Larsson and Tomoko Hayashi and B. Minev and D. Carson and S. Esener and B. Messmer and D. Messmer},
  journal={Journal of Translational Medicine},
  year={2014},
  volume={12}
}
High mobility group box protein 1 (HMGB1) acts as an endogenous danger molecule that is released from necrotic cells and activated macrophages. We have previously shown that peptide Hp91, whose sequence corresponds to an area within the B-Box domain of HMGB1, activates dendritic cells (DCs) and acts as an adjuvant in vivo. Here we investigated the underlying mechanisms of Hp91-mediated DC activation. Hp91-induced secretion of IL-6 was dependent on clathrin- and dynamin-driven endocytosis of… Expand
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