TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant

  title={TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant},
  author={Rebecca Saenz and Diahnn Futalan and Lien Leutenez and Fien Eekhout and Jessie F Fecteau and Simeon Sundelius and Stig Sundqvist and Marie Larsson and Tomoko Hayashi and Boris R. Minev and Dennis Anthony Carson and Sadik C. Esener and Bradley T. Messmer and Davorka Messmer},
  booktitle={Journal of Translational Medicine},
High mobility group box protein 1 (HMGB1) acts as an endogenous danger molecule that is released from necrotic cells and activated macrophages. We have previously shown that peptide Hp91, whose sequence corresponds to an area within the B-Box domain of HMGB1, activates dendritic cells (DCs) and acts as an adjuvant in vivo. Here we investigated the underlying mechanisms of Hp91-mediated DC activation. Hp91-induced secretion of IL-6 was dependent on clathrin- and dynamin-driven endocytosis of… CONTINUE READING
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HMGB1derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen

  • R Saenz, S Souza Cda, CT Huang, M Larsson, S Esener, D Messmer
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