TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker.

Abstract

TLRs mediate diverse signaling after recognition of evolutionary conserved pathogen-associated molecular patterns such as LPS and lipopeptides. Both TLR2 and TLR4 are known to trigger a protective immune response as well as cellular apoptosis. In this study, we present evidence that TLR4, but not TLR2, mediates an autoregulatory apoptosis of activated… (More)

Topics

Cite this paper

@article{Jung2005TLR4BN, title={TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker.}, author={Dae Young Jung and Heasuk Lee and Bo-Young Jung and Jiyeon Ock and Myung-Shik Lee and Won-Ha Lee and Kyoungho Suk}, journal={Journal of immunology}, year={2005}, volume={174 10}, pages={6467-76} }