TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans.

@article{Chassin2009TLR4AT,
  title={TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans.},
  author={C{\'e}cilia Chassin and Mathieu Picardeau and J M Goujon and Pascale Bourhy and Nathalie Quellard and Sylvie Darche and Edgar Badell and Martine Fanton d'Andon and Nathalie Winter and Sonia Lacroix-Lamand{\'e} and Dominique Buzoni-G{\^a}tel and Alain Vandewalle and Catherine Werts},
  journal={Journal of immunology},
  year={2009},
  volume={183 4},
  pages={2669-77}
}
Leptospirosis is a widespread zoonosis caused by pathogenic Leptospira interrogans that are transmitted by asymptomatic infected rodents. Leptospiral lipoproteins and LPS have been shown to stimulate murine cells via TLRs 2 and 4. Host defense mechanisms remain obscure, although TLR4 has been shown to be involved in clearing Leptospira. In this study, we show that double (TLR2 and TLR4) knockout (DKO) mice rapidly died from severe hepatic and renal failure following Leptospira inoculation… CONTINUE READING

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