TLR4 and HMGB1: partners in crime?

  title={TLR4 and HMGB1: partners in crime?},
  author={Michael S. Goligorsky},
  journal={Kidney international},
  volume={80 5},
Chen et al. confirmed the role of Toll-like receptor 4 (TLR4) in ischemic kidney injury using mice harboring spontaneous disabling mutations of the receptor and generated chimeras between TLR4-/- and TLR4+/+ mice. The major findings demonstrate the necessity of TLR4 in leukocytes, as well as in epithelial and endothelial cells, for the full-blown ischemic response and strongly suggest that the release of high-mobility group box 1 protein (HMGB1) from injured epithelia and/or endothelia… CONTINUE READING

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