TLR4/NF-κB signaling pathway-mediated and oxLDL-induced up-regulation of LOX-1, MCP-1, and VCAM-1 expressions in human umbilical vein endothelial cells.

@article{Feng2014TLR4NFBSP,
  title={TLR4/NF-$\kappa$B signaling pathway-mediated and oxLDL-induced up-regulation of LOX-1, MCP-1, and VCAM-1 expressions in human umbilical vein endothelial cells.},
  author={Y. Feng and Z. R. Cai and Y L Tang and G Hu and J. Lu and D H He and S Z Wang},
  journal={Genetics and molecular research : GMR},
  year={2014},
  volume={13 1},
  pages={
          680-95
        }
}
  • Y. FengZ. Cai S. Wang
  • Published 28 January 2014
  • Biology
  • Genetics and molecular research : GMR
This study aimed to investigate the function and signaling pathway of Toll-like receptor 4 (TLR4) in oxidized low-density lipoprotein (oxLDL)-induced up-regulated expressions of oxidized LDL receptor 1 (LOX-1), monocyte chemoattractant protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs). HUVECs were incubated with different oxLDL concentrations (0, 20, 40, 60, and 80 μg/mL) for 24 and 48 h. The influence of oxLDL on TLR4, LOX-1… 
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38 Citations
Highly Influential Citations
3
Background Citations
15
Methods Citations
1

38 Citations

Circular RNA circ_0003645 silencing alleviates inflammation and apoptosis via the NF-κB pathway in endothelial cells induced by oxLDL.

Novel function of fluvastatin in attenuating oxidized low-density lipoprotein-induced endothelial cell ferroptosis in a glutathione peroxidase4- and cystine-glutamate antiporter-dependent manner

The present study was the first to discover that fluvastatin may protect endothelial cells from ox-LDL-induced ferroptosis and dysfunction, and knockdown of GPx4 and xCT expression blunted the protective effects of fluVastatin on ox- LDL-treated endothelium cells.

DFMG attenuates the activation of macrophages induced by co-culture with LPC-injured HUVE-12 cells via the TLR4/MyD88/NF-κB signaling pathway

DFMG attenuated the activation of MP induced by co-culture with LPC-injured HUVE-12 cells, mediated via inhibition of the TLR4/MyD88/NF-κB signaling pathway in H UVE- 12 cells.

Notoginsenoside R1 inhibits oxidized low-density lipoprotein induced inflammatory cytokines production in human endothelial EA.hy926 cells.

A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development.

LOX-1: Regulation, Signaling and Its Role in Atherosclerosis

Different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis are focused on.

The role of the lectin-like oxLDL receptor (LOX-1) in traffic-generated air pollution exposure-mediated alteration of the brain microvasculature in Apolipoprotein (Apo) E knockout mice

Findings suggest that alterations in brain microvascular structure and integrity observed with MVE-exposure may be mediated, at least in part, via LOX-1 signaling.

MiR-126 promotes endothelial cell apoptosis by targeting PI 3 K / Akt in rats with lower limb arteriosclerosis obliterans

In rats with lower limb arteriosclerosis obliterans (ASO), miR-126 represses the PI3K/Akt signaling pathway to accelerate endothelial cell apoptosis and is proven via the Luciferase assay.

LOX-1 and TLR4 affect each other and regulate the generation of ROS in A. fumigatus keratitis.

Apoptosis in HUVECs induced by microRNA-616-3p via X-linked inhibitor of apoptosis protein targeting

It is demonstrated that microRNA (miR)-616-3p can directly inhibit the expression of XIAP mRNA by targeting its 3'UTR which promoted apoptosis in HUVECs.

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    Proceedings of the National Academy of Sciences of the United States of America
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