TLR4 Asp299Gly and Thr399Ile polymorphisms are very rare in the Chinese population.

@article{Hang2004TLR4AA,
  title={TLR4 Asp299Gly and Thr399Ile polymorphisms are very rare in the Chinese population.},
  author={Jingqing Hang and Wei Zhou and Hongxi Zhang and Bixiong Sun and Helian Dai and Li Su and David C. Christiani},
  journal={Journal of endotoxin research},
  year={2004},
  volume={10 4},
  pages={238-40}
}
Endotoxin is an important component of bio-aerosols that contribute to airway inflammation and airflow obstruction. Toll-like receptor 4 (TLR4) mediates the host response to bacterial lipopolysaccharide (LPS), and the Asp299Gly and Thr399Ile polymorphisms have been associated with the development of respiratory diseases. We hypothesized that TLR4 polymorphisms may be associated with a decline of lung function in cotton workers who were exposed continuously to endotoxin. We investigated these… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Increased IL-33 expression in chronic obstructive pulmonary disease.

American journal of physiology. Lung cellular and molecular physiology • 2015
View 1 Excerpt

Similar Papers

Loading similar papers…