TLR4/NF-κB/Ceramide signaling contributes to Ox-LDL-induced calcification of human vascular smooth muscle cells.

@article{Song2017TLR4NFBCeramideSC,
  title={TLR4/NF-κB/Ceramide signaling contributes to Ox-LDL-induced calcification of human vascular smooth muscle cells.},
  author={Yan Song and Menglin Hou and Zhenlin Li and Chufan Luo and Jing-song Ou and Huimin Yu and Jianyun Yan and Lihe Lu},
  journal={European journal of pharmacology},
  year={2017},
  volume={794},
  pages={45-51}
}
Vascular calcification is a major feature of advanced atherosclerosis and highly associated with cardiovascular diseases. Oxidized low density lipoprotein (Ox-LDL) has been recognized as a critical risk factor for atherosclerosis and osteogenic differentiation of vascular smooth muscle cells (VSMCs). Previous studies have demonstrated that toll like receptor 4 (TLR4) is highly expressed in atherosclerotic lesions and participates in the progression of atherosclerosis. However, the role of TLR4… CONTINUE READING