TLR3-mediated synthesis and release of eotaxin-1/CCL11 from human bronchial smooth muscle cells stimulated with double-stranded RNA.

@article{Niimi2007TLR3mediatedSA,
  title={TLR3-mediated synthesis and release of eotaxin-1/CCL11 from human bronchial smooth muscle cells stimulated with double-stranded RNA.},
  author={Kyoko Niimi and Koichiro Asano and Yoshiki Shiraishi and Takeshi Nakajima and Misa Wakaki and Junko Kagyo and Takahisa Takihara and Yusuke Suzuki and Koichi Fukunaga and Tetsuya Shiomi and Tsuyoshi Oguma and Koichi Sayama and Kazuhiro Yamaguchi and Yukikazu Natori and Misako Matsumoto and Tsukasa Seya and Mutsuo Yamaya and Akitoshi Ishizaka},
  journal={Journal of immunology},
  year={2007},
  volume={178 1},
  pages={489-95}
}
Respiratory infections with RNA viruses, such as rhinovirus or respiratory syncytial virus, are a major cause of asthma exacerbation, accompanied by enhanced neutrophilic and/or eosinophilic inflammation of the airways. We studied the effects of dsRNA synthesized during RNA virus replication, and of its receptor, TLR3, on the synthesis of eosinophilic chemokines in bronchial smooth muscle cells (BSMC). Synthetic dsRNA, polyinosinic-cystidic acid (poly(I:C)), induced the synthesis of… CONTINUE READING