TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression.

@article{Park2006TLR3mediatedSI,
  title={TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression.},
  author={Chanhee Park and Soojin Lee and Ik-Hyun Cho and Hyun Kyoung Lee and Donghoon Kim and Se-Young Choi and Seog Bae Oh and Kyungpyo Park and Joong Soo Kim and Sung Joong Lee},
  journal={Glia},
  year={2006},
  volume={53 3},
  pages={248-56}
}
Viral infection is one of the leading causes of brain encephalitis and meningitis. Recently, it was reported that Toll-like receptor-3 (TLR3) induces a double-stranded RNA (dsRNA)-mediated inflammatory signal in the cells of the innate immune system, and studies suggested that dsRNA may induce inflammation in the central nervous system (CNS) by activating the CNS-resident glial cells. To explore further the connection between dsRNA and inflammation in the CNS, we have studied the effects of… CONTINUE READING