TLR2 signaling subpathways regulate TLR9 signaling for the effective induction of IL-12 upon stimulation by heat-killed Brucella abortus

Abstract

Brucella abortus is a Gram-negative intracellular bacterium that induces MyD88-dependent IL-12 production in dentritic cells (DCs) and a subsequent protective Th1 immune response. Previous studies have shown that the Toll-like receptor 2 (TLR2) is required for tumor-necrosis factor (TNF) production, whereas TLR9 is responsible for IL-12 induction in DCs… (More)
DOI: 10.1038/cmi.2012.11

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@article{Zhang2012TLR2SS, title={TLR2 signaling subpathways regulate TLR9 signaling for the effective induction of IL-12 upon stimulation by heat-killed Brucella abortus}, author={Chun-Yan Zhang and Nan Bai and Zhu-hong Zhang and Ning Liang and Lan Dong and Rong Xiang and Cheng-hu Liu}, journal={Cellular and Molecular Immunology}, year={2012}, volume={9}, pages={324-333} }