TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity.

@article{Zaehringer2008TLR2P,
  title={TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity.},
  author={Ulrich Zaehringer and Buko Lindner and Seiichi Inamura and Holger Heine and Christian Alexander},
  journal={Immunobiology},
  year={2008},
  volume={213 3-4},
  pages={205-24}
}
Of all pattern recognition receptors (PRR) in innate immunity, Toll-like receptor 2 (TLR2) recognizes the structurally broadest range of different bacterial compounds known as pathogen-associated molecular patterns (PAMPs). TLR2 agonists identified so far are lipopolysaccharides (LPSs) from different bacterial strains, lipoproteins, (synthetic) lipopeptides, lipoarabinomannans, lipomannans, glycosylphosphatidylinositol, lipoteichoic acids (LTA), various proteins including lipoproteins and… CONTINUE READING
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