TLR2 is expressed on activated T cells as a costimulatory receptor.

  title={TLR2 is expressed on activated T cells as a costimulatory receptor.},
  author={Mousa Komai-Koma and Louise Jones and Graham S Ogg and D -M. Xu and Foo Yew Eddy Liew},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 9},
Toll is the founder of a group of pattern recognition receptors that play a critical role in the innate immunity in Drosophila. At least 10 distinct Toll-like receptors (TLRs), recognizing pathogen-associated molecular patterns, have now been identified in humans. Most investigations on TLRs have focused on cells of the innate system. We report here that naïve human T cells expressed high levels of cell-surface TLR2 after activation by anti-T cell receptor antibody and IFN-alpha. Activated… CONTINUE READING
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